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The game also offers a Free Spins bonus with multipliers up to 500x your bet.<br><br>Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and had participants from different geographic areas. This type of heterogeneity, which is essential for pragmatic trials to be reliable and reduce bias in results, is also necessary. However, too much heterogeneity can lead to problems with the design of the trial.<br><br>Pragmatic Play is also a major player in the live casino market, offering an array of table games that are classic such as Blackjack and Roulette in a variety of versions. The live studios of Pragmatic Play in Romania and Malta offer customers an authentic gaming experience as well as a broad range of virtual betting options. The company also offers a variety of games that make online gambling more enjoyable and engaging. 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This can help you become familiar with the game's rules and features prior to playing with real money.<br><br>Legality<br><br>Pragmatic Play is known for its top-quality games and also for providing an outstanding user experience. The software is available on mobile devices as well as in various languages. Despite its relative youth it has already established itself as a top casino gaming platform. The latest releases include Wolves 5 reel video slot with a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.<br><br>Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are usually commissioned by policy makers and practitioners to aid in their decision-making. They can be used to determine the cause-effect relationship of an intervention with its outcomes. However, they should not be used to substitute for explanation trials.<br><br>The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or clinical hypothesis as well as pragmatic trials, which inform the policy and practice of. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a pragmatic trial that include recruitment, design and delivery of the intervention, and follow-up.<br><br>There is a positive increase in the number of pragmatic trials published. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the subject of pragmatism. It is important to keep in mind that the majority of studies were conducted in primary-care settings.