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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are usually focused on the practical aspects of research design, like the recruitment process and consent, adherence, and the use of standard equipment.

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A pragmatic trial that uses a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for pragmatic trials to be valid and also reduces the chance of bias in the results. However excessive heterogeneity could result in problems with the design of the trial.

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The goal of pragmatic trials is to simulate real-life scenarios and 프라그마틱 추천 gain the highest level of validity externally. They are typically ordered by policymakers and practitioners to guide their decisions. They can be used to determine the causality of an intervention with its outcomes. However, they shouldn't be used in lieu for the use of explanation studies.

The concept of pragmatism is controversial, and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or 프라그마틱 무료 clinical hypothesis as well as pragmatic trials, which inform policy and practice decisions. They also suggested a framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the elements of a pragmatic study that include the recruitment process, the design and delivery of the intervention, and monitoring.

There is an encouraging increase in the number of pragmatic trials published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) produced 34 articles, shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to note, however, that the majority were conducted in primary-care settings.