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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often focused on practical aspects of the study design, including the recruitment process and consent as well as adherence to the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and participants from various geographical areas. This kind of heterogeneity, which is vital for a pragmatic trial to be valid and reduce bias in results, is also necessary. However excessive heterogeneity could cause problems with the design of the trial.

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Pragmatic Play offers not only mobile-friendly slot machines, but also table games and live casino. Pragmatic Play is licensed and regulated by a variety of regulatory bodies, including the Malta Gaming Authority and UK Gambling Commission. The games offered by the company are secured with high-end encryption, and its security team is on hand to help players with any issues.

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Legality

Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. Its software is designed to work on mobile devices and supports multiple languages. Despite its relatively young age it has established itself as a top casino gaming platform. Wolves is one of its latest releases which is a five-reel slot machine that has a high RTP and impressive graphics. Other notable games include Wolf Gold and 프라그마틱 무료스핀 Chilli Heat.

The purpose of pragmatic trials is to simulate real-life situations and achieve the highest level of validity externally. They are usually commissioned by practitioners and policy makers to inform their decision making. They can be used to determine the causality of an intervention and its effects. However, they should not, be used to replace the need for explanation studies.

The concept of pragmatism is controversial, and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a practical study which includes the recruitment, design, and delivery of the intervention and follow-up.

There is an encouraging trend in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) produced 34 articles, as shown in red in Figure 2. This is an indication that the health science community is becoming more acquaint to the issue of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary care settings.