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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often characterized as a focus on the practical aspects of designing a study that include the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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A pragmatic study that involves different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be valid, and it also helps to reduce the chance of bias in the results. However, too much heterogeneity could cause issues with the trial design.

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Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are usually ordered by policymakers and practitioners in order to guide their decisions. They also provide a useful method to determine the causal relationship between an intervention and its results. They should not, however, be used to replace explanation studies.

The idea of pragmatism is controversial and 프라그마틱 정품확인방법, images.google.is, there are doubts regarding whether pragmatic trials could be used to replace explanation tests or if they are an addition to them. Schwartz and Lellouch1 made a distinction between explanatory studies, which confirm the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic study that includes recruitment, design, implementation of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health sciences community is becoming more acquaint to the subject of pragmatics. It is important to note, however, that the majority of studies were conducted in primary care settings.