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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are typically characterized by a focus on practical aspects of the research design, like the recruitment and consent process in adherence, as well as the use of routinely available equipment.

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A pragmatic trial that uses different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for practical trials to be valid, and it also helps reduce bias in the results. However excessive heterogeneity could cause problems with the design of the trial.

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Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are typically requested by practitioners and policymakers to inform their decisions. They can be used to determine the cause-effect relationship of an intervention with its outcomes. However, 프라그마틱 슬롯 무료 they should not, be used to replace explanatory studies.

The idea of pragmatism is controversial and there are doubts about whether pragmatic trials should be used to replace explanation tests or if they should be a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which prove the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool sought to define the features of a pragmatic study, including recruitment, design and delivery of the intervention, as well as monitoring.

The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs), yielded 34 articles, which are shown in red in Figure 2. This is a sign that the health sciences community is becoming more acquaint to the subject of pragmatism. It is important to note that the majority of these studies were conducted in primary care settings.