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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are usually characterized by a focus on the practical aspects of the study design, including the recruitment and consent process as well as adherence to the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from different geographic areas. This kind of heterogeneity, which is vital for a pragmatic trial to be valid and to reduce bias in the results is also essential. However, 프라그마틱 추천 슬롯 추천 (Https://Hildebrandt-Mclean-4.Technetbloggers.De) too much heterogeneity can cause issues with the design of the trial.

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The purpose of pragmatic trials is to mimic real-life situations and achieve maximum credibility externally. They are typically commissioned by policymakers and practitioners to inform their decisions. They are also a good method to determine the causality between an intervention and its results. However, they shouldn't be used to substitute for explanation studies.

The pragmatism concept is controversial, and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which support the validity of a physiological or clinical hypothesis, as well as pragmatic trials, which inform policy and practice decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic research study that includes recruitment, design, delivery of the intervention, and follow-up.

There is a growing increase in the number of pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more sensitive to the subject of pragmatics. It is important to remember that the majority of these studies were conducted in primary-care settings.