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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often characterized as a focus on the practical aspects of study design that include recruitment and 프라그마틱 슬롯 무료 consent, adherence and the use of standard equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and included participants from different geographical regions. This kind of heterogeneity, which is vital for pragmatic trials to be valid and to reduce bias in the results is also essential. Too much heterogeneity, however could cause issues with the design of the trial.

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The aim of pragmatic trials is to mimic real-life situations and achieve maximum validity externally. They are usually commissioned by policy makers and practitioners to guide their decision-making. They can be used to determine the cause-effect relationship of an intervention with its outcomes. They should, however, not, 프라그마틱 무료슬롯 체험 (find more) be used to replace explanation studies.

The pragmatism idea is controversial and there are concerns regarding whether pragmatic trials could be used to replace explanation tests or if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the clinical or physiological hypothesis, and pragmatic trials, which guide the practice and policy decisions. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool sought to define the elements of a pragmatic trial that include recruitment, design and delivery of the intervention, and follow-up.

There is an encouraging increase in the number pragmatic trials that are published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary care settings.