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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often described by their focus on practical aspects of study design, including recruitment and consent, adherence and the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed different investigators and 프라그마틱 슬롯무료 정품 (he said) included participants from different geographical regions. This type of heterogeneity which is essential for a pragmatic trial to be valid and lessen the chance of bias is also essential. However, too much heterogeneity can result in problems with the design of the trial.

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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are usually requested by practitioners and policy makers to inform their decision making. They can also be a great way to identify the causal relationship between the intervention and its effects. However, they should not be used to substitute for explanatory trials.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or clinical hypothesis and pragmatic trials, which guide the policy and practice of. They also suggested an approach to pragmatic trials, called PRECIS.2 This tool was designed to define the features of a pragmatic trial, including recruitment, design and delivery of the intervention, as well as the follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the terms pragmatic and naturalistic, restricted to randomized controlled trials (RCTs), yielded 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary-care settings.