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Pragmatic trials are studies designed to provide information for real-world clinical practice. They are often described as a focus on the practical aspects of designing a study that include the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used various investigators and participants from different geographical regions. This type of heterogeneity that is crucial for pragmatic trials to be reliable and lessen the chance of bias is also essential. However excessive heterogeneity could lead to issues with the design of the trial.
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Legality
Pragmatic Play is known for its top-notch games, and for providing a superior user experience. Its software is designed to work with mobile devices and supports various languages. Despite its relative youth, it has already established itself as a premier gaming platform for casinos. The most recent releases include Wolves 5 reel video slot that has a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.
The purpose of pragmatic trials is to replicate real-life situations and achieve the highest level of validity externally. They are usually commissioned by policy makers and practitioners to inform their decision making. They are also a good way to identify the cause-effect relationship between an intervention and its results. However, they shouldn't be used in lieu for explanation trials.
The concept of pragmatism is controversial, and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis as well as pragmatic trials, which guide the practice and policy decisions. They also suggested a framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the elements of a pragmatic trial which includes the recruitment process, the design and implementation of the intervention, and follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.