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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often characterized by a focus on the practical aspects of study design, such as the recruitment and consent process in adherence, as well as the use of standard equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and participants from various geographical areas. This kind of heterogeneity, which is essential for a pragmatic trial to be reliable and to reduce bias in the results is also essential. However too much heterogeneity could result in issues with the design of the trial.
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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are typically commissioned by policy makers and practitioners to aid in their decision-making. They also provide a useful method of determining the causality between the intervention and its effects. However, they should not be used to replace explanatory studies.
The pragmatism idea is controversial and there are doubts regarding whether pragmatic trials could replace explanatory tests or if they should be a complement to them. Schwartz and 프라그마틱 슬롯 체험 Lellouch1 suggested a distinction between explanatory studies, which confirm the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the characteristics of a pragmatic study which includes the recruitment process, the design and implementation of the intervention, 프라그마틱 무료 as well as follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, limited to randomized controlled trials (RCTs) resulted in 34 articles, shown in red in Figure 2. This is an indication that the health sciences community is becoming more acquaint to the subject of pragmatism. It is important to note that the majority were conducted in primary-care settings.